A cosmotopological relation for a unified field theory

I present an argument, based on the topology of the universe, why there are three generations of fermions. The argument implies a preferred unified gauge group of SU(5), but with SO(10) representations of the fermions. The breaking pattern $SU(5) \to SU(3) \times SU(2) \times U(1)$ is preferred over the pattern $SU(5) \to SU(4) \times U(1)$. On the basis of the argument one expects an asymmetry in the microwave data, which might have been detected already.Comment: 6 page

A theorem on topologically massive gravity

We show that for three dimensional space-times admitting a hypersurface orthogonal Killing vector field Deser, Jackiw and Templeton's vacuum field equations of topologically massive gravity allow only the trivial flat space-time solution. Thus spin is necessary to support topological mass.Comment: published in Classical and Quantum Gravity 13 (1996) L2

G\"odel Type Metrics in Three Dimensions

We show that the G{\" o}del type Metrics in three dimensions with arbitrary two dimensional background space satisfy the Einstein-perfect fluid field equations. There exists only one first order partial differential equation satisfied by the components of fluid's velocity vector field. We then show that the same metrics solve the field equations of the topologically massive gravity where the two dimensional background geometry is a space of constant negative Gaussian curvature. We discuss the possibility that the G{\" o}del Type Metrics to solve the Ricci and Cotton flow equations. When the vector field $u^{\mu}$ is a Killing vector field we finally show that the stationary G{\" o}del Type Metrics solve the field equations of the most possible gravitational field equations where the interaction lagrangian is an arbitrary function of the electromagnetic field and the curvature tensors.Comment: 17 page

Topologically massive gravito-electrodynamics: exact solutions

We construct two classes of exact solutions to the field equations of topologically massive electrodynamics coupled to topologically massive gravity in 2 + 1 dimensions. The self-dual stationary solutions of the first class are horizonless, asymptotic to the extreme BTZ black-hole metric, and regular for a suitable parameter domain. The diagonal solutions of the second class, which exist if the two Chern-Simons coupling constants exactly balance, include anisotropic cosmologies and static solutions with a pointlike horizon.Comment: 15 pages, LaTeX, no figure

Spinor formulation of topologically massive gravity

In the framework of real 2-component spinors in three dimensional space-time we present a description of topologically massive gravity (TMG) in terms of differential forms with triad scalar coefficients. This is essentially a real version of the Newman-Penrose formalism in general relativity. A triad formulation of TMG was considered earlier by Hall, Morgan and Perjes, however, due to an unfortunate choice of signature some of the spinors underlying the Hall-Morgan-Perjes formalism are real, while others are pure imaginary. We obtain the basic geometrical identities as well as the TMG field equations including a cosmological constant for the appropriate signature. As an application of this formalism we discuss the Bianchi Type $VIII - IX$ exact solutions of TMG and point out that they are parallelizable manifolds. We also consider various re-identifications of these homogeneous spaces that result in black hole solutions of TMG.Comment: An expanded version of paper published in Classical and Quantum Gravity 12 (1995) 291

Dynamics and energetics of the mammalian phosphatidylinositol transfer protein phospholipid exchange cycle

Phosphatidylinositol-transfer proteins (PITPs) regulate phosphoinositide signaling in eukaryotic cells. The defining feature of PITPs is their ability to exchange phosphatidylinositol (PtdIns) molecules between membranes, and this property is central to PITP-mediated regulation of lipid signaling. However, the details of the PITP-mediated lipid exchange cycle remain entirely obscure. Here, all-atom molecular dynamics simulations of the mammalian StART-like PtdIns/phosphatidylcholine (PtdCho) transfer protein PITP alpha, both on membrane bilayers and in solvated systems, informed downstream biochemical analyses that tested key aspects of the hypotheses generated by the molecular dynamics simulations. These studies provided five key insights into the PITP alpha lipid exchange cycle: (i) interaction of PITP alpha with the membrane is spontaneous and mediated by four specific protein substructures; (ii) the ability of PITP alpha to initiate closure around the PtdCho ligand is accompanied by loss of flexibility of two helix/loop regions, as well as of the C-terminal helix; (iii) the energy barrier of phospholipid extraction from the membrane is lowered by a network of hydrogen bonds between the lipid molecule and PITP alpha; (iv) the trajectory of PtdIns or PtdCho into and through the lipidbinding pocket is chaperoned by sets of PITP alpha residues conserved throughout the StART-like PITP family; and (v) conformational transitions in the C-terminal helix have specific functional involvements in PtdIns transfer activity. Taken together, these findings provide the first mechanistic description of key aspects of the PITP alpha PtdIns/PtdCho exchange cycle and offer a rationale for the high conservation of particular sets of residues across evolutionarily distant members of the metazoan StART-like PITP family.Peer reviewe

Mass and angular momentum of asymptotically AdS or flat solutions in the topologically massive gravity

We study the conserved charges of supersymmetric solutions in the topologically massive gravity theory for both asymptotically flat and constant curvature geometries.Comment: REVTEX4, 8 pages, no figures, added 2 references and a few clarifying remark

Reductions in all-cause, cancer, and coronary mortality in statin-treated patients with heterozygous familial hypercholesterolaemia: a prospective registry study

AIMS: To examine the changes in coronary, all-cause, and cancer mortality in patients with heterozygous familial hypercholesterolaemia (FH) before and after lipid-lowering therapy with statins. METHODS AND RESULTS: A total of 3382 patients (1650 men) aged <80 years were recruited from 21 lipid clinics in the United Kingdom and followed prospectively between 1980 and 2006 for 46 580 person-years. There were 370 deaths, including 190 from coronary heart disease (CHD) and 90 from cancer. The standardized mortality ratio (compared with the population in England and Wales) was calculated before and from 1 January 1992. In patients aged 20-79 years, CHD mortality fell significantly by 37% (95% CI = 7-56) from 3.4- to 2.1-fold excess. Primary prevention resulted in a 48% reduction in CHD mortality from 2.0-fold excess to none, with a smaller reduction of nearly 25% in patients with established disease. Coronary mortality was reduced more in women than in men. In patients without known CHD at registration, all-cause mortality from 1992 was 33% (21-43), lower than in the general population, mainly due to a 37% (21-50) lower risk of fatal cancer. CONCLUSION: The results emphasize the importance of early identification of FH and treatment with statins